12 oz. Mouse - Season 1

Mouse Fitzgerald is hired for a job by Shark. His first task is to transport a Rectangular Businessman to an important meeting, but Fitz instead takes him to a porno set and then blows up the building. After robbing a bank, Fitz and his friend Skillet buy large amounts of alcohol and cause mayhem all over town. Fitz then returns to Shark who reviews his failed assignment. After discovering Shark is bulletproof (by shooting him) Fitz decides to take Shark's next job.

Shark gives Fitz his next job: To help Eye, a giant eye, get "50 mil" owed to him by the magical Golden Joe. Fitz approaches Joe at the bar and hatches a plan to trick Shark and Eye. Fitz and Joe spend the "50 mil" to buy a tank and break Skillet out of prison. Fitz then blows up the building. When Eye comes to reclaim his money, Fitz admits he "pissed it away" and sings about the sunset.

Fitz has mysterious dreams about his past, when he had a wife and a child. Skillet brings him a package containing a homing corndog. Meanwhile, Shark meets with Rectangular Businessman, Eye, and Man/Woman to show them a slideshow about "asprind", which he says, leads to rabies. The corndog leads Fitz to Roostre, a corndog farmer who seems to know things about Fitz's past. He mentions to Fitz that a person named C.J. Muff left Q109. The New Guy, a red ghost-like being, kidnaps Skillet and tortures him withexoticamusic and hula-hooping.

A giant spider appears in Fitz's house and weaves an arrow in its web. Skillet manages to escape from The New Guy and rejoins Fitz. When Fitz discovers new clues, the Clock appears and doses him with time gas, compelling him to destroy the evidence. Fitz and Skillet break into a music store and rock out. Peanut Cop and Producer Man show up, and Producer Man offers Fitz a record deal – until his head is mysteriously sliced in half. Meanwhile, Liquor reads a letter erroneously delivered to him written by someone named "Mosquitor." A large amount of blood drips from the letter. Fitz delivers the record he made to Shark. Its title is "F-Off." Back at home, Fitz finds a severed hand that Shark apparently left under his bed. Shark says it's also a record and tells him to "Spin it."

Shark threatens Fitz, introducing him to Pronto, a deadly archer. Fitz decides he's hungry and heads to the diner, where he and Skillet get into a gun fight with someone they don't even know. Meanwhile, Shark and the Rectangular Businessman gather a large crowd of people and place strange helmets on their heads. Fitz, Skillet and Man/Woman go to the bar where they find Rhoda, the bartender, dead, shot full of arrows.

A new Rhoda appears and tries to pass off the dead Rhoda as "a joke." Fitz incapacitates Man/Woman and forces a reluctant Rhoda to give him answers about what's going on. Fitz travels to the corndog farm, taking Roostre, Golden Joe, and Peanut Cop captive, and has another flashback in which his wife encounters the Shadowy Figure. Roostre reveals that C.J. Muff's real name is Bermingham. At the farm, The New Guy appears and tries to hypnotize everyone with his music. Shark and Rectangular Businessman discover Rhoda is cooperating with Fitz.

Rectangular Businessman executes Rhoda by telepathically slicing his head in half, revealing a fire-breathing snake inside. Fitz takes down The New Guy with a rocket-powered skateboard and helps Skillet and the rest escape the shack. Skillet discovers an invitation to a fancy party Shark is holding, and Fitz decides to crash it. Shark and Rectangular Businessman get fed up with the Eye and decide to punish him. Rectangular Businessman makes Pronto enter Fitz's house to free the Hand from his icebox. The Hand subsequently cuts off the Eye's leg with a pair of shears. At the party, Fitz is sucked into a passageway behind a bookshelf. As Skillet is shot with a dart and Eye collapses in a puddle of blood, Shark watches from his control room and laughs evilly.