Spider-Man - Season 4

Tombstone, whilst incarcerated in Rooker's Island, plots revenge on Robbie Robertson as Robbie previously caused his arrest. In exchange for assisting cell-mate Richard Fisk in a few brawls in prison, Richard requests that his father, The Kingpin, frame Robbie as a criminal mastermind.

Doctor Octopus attempts to blackmail Anastasia Hardy into paying him ransom money in order to fund his dangerous experiments, by threatening to reveal that Felicia's father was the crook known as "The Cat".

The Kingpin blackmails John Hardesky into revealing a secret super-soldier formula by making threats against Felicia. After Hardesky reveals his secrets, Landon is able to recreate and improve the formula for the crime lord. Kingpin uses the serum to transform Felicia into a "black cat", and forces her to carry out his crimes until he can create more serum. 

Spider-Man teams with the Black Cat in an attempt to confront Kraven the Hunter. After Kraven eludes the two heroes, there are various reports of attacks. Debra Whitman decides to investigate and she, Black Cat, Flash Thompson, and Dr. Curt Connors hunt for clues, and succeed in identifying the DNA as female. It turns out that Dr. Crawford had been given the same serum that drove Kraven crazy, in order to heal her from a fatal disease; unfortunately, it mutated her into a feral form. Luckily, Dr. Conners creates a serum that restores Dr. Crawford's mind, allowing her to live as Kraven's equal.

Alistair Smythe, currently working as Silvermane's top scientist, kidnaps the Black Cat. He then bribes Spider-Man into capturing either the Scorpion or the Vulture, who both have unique DNA samples which are essential for Silvermane if he is to restore adulthood, in exchange for her release.

The mutated Morbius is found by scientists, and taken back to New York to have his condition studied. The Insidious Six kidnap Morbius for Dr. Landon, who manages to revert Morbius back to his previous vampire form; however, in the confusion, Morbius escapes while Spider-Man fights his foes.

After a confrontation with Miriam the Vampire Queen, Blade is horrified to learn that she was once his human mother. Using a psychic link, Miriam finds Morbius, who is fighting his vampire hunger, to find out what unconventional means he used to become one of her kind. Learning of the Neogenic Recombinator, Miriam plans to use the device to create more vampires to serve her.

Trapped in the limbo between portals, the Green Goblin telepathically calls out to his son, Harry Osborn. Keeping his true identity a secret, he promises Harry that he will see his father soon if he becomes the next Green Goblin. When confronted by Spider-Man about the truth, Harry is shocked when the Green Goblin shows him that he's his father; unfortunately this causes whatever little sanity Harry had left to collapse, making him decide to truly take after his father by continuing on as the second Green Goblin. However, he's knocked out and sent to Ravencroft for help. An angry Norman watches from limbo, but is more shocked when he sees Mary Jane appear at the site of the battle. 

After a brief fight with Mysterio, Peter learns that Mary Jane finally got her big break in recreating the movie role made famous by an actress named Miranda Wilson. However, it was a trap set by Miranda, who had survived the accident on the filming of her movie; Mysterio had taken on his supervillain identity to gather funds to rebuild her body as a cyborg. However, Miranda had the mistaken assumption that the machinery would transfer her mind into a body similar to hers - Mary Jane. Unfortunately, this was never to be; unable to let the world see what became of her, Miranda starts a self-destruct sequence for the studio, while Mysterio chooses to die with her. Watching from a distance, Spider-Man removes his mask in front of Mary Jane.

Peter proposes and Mary Jane accepts, much to Anna Watson's discomfort. Peter and Mary Jane ask Curt Connors to give Mary Jane away at the wedding, when they are interrupted by three giant lizards who claim the Doc is their father and kidnap him and Mary Jane. They're taken down to sewer, with Spider-Man in pursuit, and Doc becomes the Lizard again.

When crime lord, Iceberg, finds out that Hobie doesn't feel that he's getting a fair cut, he has his boys attempt to kill him. After narrowly escaping that fate, Hobie knows he needs to get out of town. He steals a passer-by's purse in order to fund his new trip. It turns out to be Mary Jane's purse when she and Peter are in the process of apartment hunting, but was stopped by Spider-Man and Hobie is sent to jail for violating his parole. While in jail, he saves Richard Fisk from an attempt on his life. As payment, the Kingpin arranges for a hot shot lawyer to enable Hobie's release, and gives him a special suit. He uses the costume to get back at his old boss, Iceberg.